Hypertension in midlife anticipate cognitive disorders
An analysis of cerebrospinal fluid samples of adults without cognitive impairment revealed that participants with a high value of blood pressure were more likely to have biomarkers of Alzheimer's disease (AD).
The study included 177 adults, 55-100 years without cognitive impairment , previous stroke or EA . All of them took the pulse pressure and underwent a lumbar puncture to determine the levels of β -amyloid 1-42 ( Aβ1 -42 ) and phosphorylated tau (p- tau ) in cerebrospinal fluid .
In a multivariate analysis , increased blood pressure was significantly associated with an increased level of p- tau ( p = 0.002 ), a reduction of Aβ1 -42 (p = 0.01) and a higher ratio p- tau/Aβ1-42 ( p <0.001). After controlling for important covariates , blood pressure remained associated with the level of p- tau ( p = 0.0196 ) and p-tau/Aβ1-42 (p < 0.001 ) relationship, but not Aβ1 -42 (p = 0.35).
These results suggest that high blood pressure would be associated with the appearance of signs of AD keys that cause the loss of brain cells. Scientists noted that the increase in blood pressure was associated with all biomarkers evaluated in adults 55-70 years , but not in 70-100 years.
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